Julie Cramer, PhD, MS
Education and Experience
Julie recently had the role of scientist and clinical trial coordinator at NanoVision Diagnostics, where their goal was to utilize nanoscale measurements to improve cancer diagnosis and predict risk of progression. In her PhD program at the University of Pittsburgh, Julie was trained in cellular and molecular pathology and established new protocols for the study of human intestinal stem cells and their role in intestinal cancer. This led to the establishment of collaborations in both academia and industry, broadening her understanding of the relationship between the two and how they can work together. Therefore, when the opportunity arose to begin working with a start-up company using technology that was developed at the University of Pittsburgh, Julie jumped at the chance. Julie is also the 2017 vice-chair of the Pittsburgh chapter of Women In Bio, where their mission is to promote knowledge sharing among women, impact regional economic growth and stimulate empowerment among women leaders through entrepreneurship, innovation, education, and mentorship.
Education
PhD, Pathology, University of Pittsburgh School of Medicine, 2014MS, Biology, Youngstown State University, 2005
BS, Biology, Youngstown State University, 2003
Research Experience
Graduate Student Researcher, Department of Pathology, University of Pittsburgh, Advisor: Eric Lagasse, PhD- Established culturing system to expand and characterize primary stem cells of the human small and large intestine resulting in the identification of dramatic cellular and molecular differences that may relate to the increased incidence of colon cancer compared to small intestinal cancer. Collaborative Projects:
- Investigated the role of protein tyrosine phosphatase, PTP4A3, on cancer stem cells in a mouse model of colitis-associated colon cancer.
- Determined three-dimensional culture conditions for the investigation of the protective effects of a small molecule inhibitor on human small intestinal cells after irradiation.
- Development of reporter system to allow the identification of compounds that push differentiation of colon cancer stem cells and cause elimination of self-renewal potential.
- Identified unique proteins in the anaerobic metabolic pathway of p-cresol, a toxic aromatic tumor promoter in disinfectants and preservatives, as seen in Thauera aromatica strain T1.
- Developed consistent cell culture and protein isolation techniques for Penicillium marneffei, a dimorphic, opportunistic fungal pathogen. Proteomic profiling indicated several candidate proteins that were differentially expressed and thought to play a role in its pathogenicity.
Commercial Translation Experience
Scientist, NanoVision Diagnostics, Inc.-
Julie was the first employee at NanoVision Diagnostics, Inc, which had licensed a technology for commercialization from the University of Pittsburgh. There, she participated in all aspects of a start-up company, from fund-raising to data analysis. She managed all pathology aspects of development, engaging clinical pathologists and physicians as needed. She established and maintained relationships with all of their physician and investigator collaborators, making sure that the company’s goal and planned clinical trials matched that of clinical need. Furthermore, she learned the key aspects of the business side of a start-up, including investor relations, reimbursement, market research and contract review and adherence.
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Stage location: http://stage.scivelo.pitt.edu/meet-our-translators/
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