Ayantika (Annie) Ghosh, PhD, MS

Education

PhD, Biochemistry, Bose Institute, Calcutta, India 2009
MS, Biochemistry, University of Calcutta, India, 2002
BS, Chemistry, Sambalpur University, India, 2000

Research Experience

Post-Doctoral Research

Research Associate, Department of Surgery

Led independent studies on molecular modeling of alpha1-antitrypsin deficiency disease in immunocompromised mice by repopulating their livers with human hepatocytes and treatment with human specific AAV virus expressing the mutant allele of alpha-1 antitrypsin.

Postdoctoral Research Scholar, Department of Pediatrics-Gastroenterology & Hepatology

Successfully led and completed research projects on molecular signaling pathways implicated in inflammatory bowel disease and intra-hepatic Cholestasic disease.

• McClain L, Zhi Y, Cheng HH, Ghosh A, Piazza P, Yee MB, Kumar S, Milosevic J, Bloom DC, Boger R, Kinchington PR, Yolken RH, Nimgaonkar VL, D’Aiuto L (2015) Broad-spectrum non-nucleoside inhibitors of human herpesviruses. Antiviral Research.
• Soler DM Ghosh A, Chen F, and Shneider BL (2014) A single element in the 3’UTR of the apical sodium dependent bile acid transporter controls both stabilization and destabilization of mRNA. Biochemical Journal 462(3): 547-553.
• Ghosh A, Chen F, Banerjee S, Xu M and Shneider BL (2014) c-Fos Mediates Repression of the Apical Sodium Dependent Bile Acid Transport by Fibroblast Growth Factor-19 in Mice. American Journal of Physiology & Gastrointestinal Liver Physiology 306(2): G163-71.
• Chen F, Ghosh A, Shneider B (2013) Phospholipase D2 Mediates signaling by ATPase Class I Type 8B Membrane 1. Journal of Lipid Research 54(2):379-85.

Graduate Research
Studied Cell death signaling pathways in acetaminophen induced liver damage.

• Ghosh A, Sil PC (2009) Protection of acetaminophen induced mitochondrial dysfunctions and hepatic necrosis via NF-kappa B pathway: role of a novel plant protein. Chemico-Biological Interactions 177(2), 96-106.
• Ghosh A, Sil PC (2008) A protein from Cajanus indicus L protects liver and kidney against mercuric chloride induced oxidative stress. Biological and Pharmaceutical Bulletin 31(9), 1651-1658.
• Ghosh A. Sarkar K, Sil PC (2007) Anti-oxidative effect of a protein from Cajanus indicus L against acetaminophen-induced hepato-nephrotoxicity in vivo. Journal of Biochemstry and Molecular Biology 40, 1039-1049.
• Ghosh A, Sarkar K, Kinter A, Mazumder B, Sil PC (2006) Purification and characterization of a 43kD hepatoprotective protein from the herb Cajanus indicus L. Protein J. 25, 411-421. * Equal contribution
• Ghosh A, Sil PC (2006) A 43kD protein from the leaves of the herb, Cajanus indicus
  L, modulates chloroform induced hepatotoxicity in vitro. Drug and Chemical Toxicology 29, 397-
• Ghosh A, Sarkar K, Sil PC (2006) Protective effect of a 43kD protein from the leaves of the herb, Cajanus indicus L on chloroform induced hepatic-disorder. Journal of Biochemstry and Molecular Biology 39, 197-207.
• Sarkar K, Ghosh A, Si, PC (2005) Preventive and curative role of a 43kD protein from the leaves of the herb Cajanus indicus L on thioacetamide induced hepatotoxicity in vivo. Hepatology Research 33, 39-49.

Undergraduate Research
Contributing member of an international research group to identify and develop a vaccine for a virulent strain of cholera virus that was later submitted to World Health Organization (WHO).

• Dutta S, Ghosh A, Ghosh K, Dutta D, Bhattacharya S, Nair GB, and Shin-ichi (2003) Newly emerged multiple-antibiotic-resistant Shigella dysenteriae Type 1 Strains in and around Kolkata, India, Are Clonal. Journal of Clinical Microbiology 41 (12): 5833-5834

Commercial Translation Experience

sciVelo
Commercial Translation Architect

Help University of Pittsburgh investigators reach their commercial translational goals by facilitating and aligning shared incentives, solution scopes and resources between Pitt and industry.

University of Pittsburgh Technology Transfer Office (Innovation Institute), Pittsburgh, PA
Licensing Associate Intern                                                                                                                           

• Reviewed and evaluated the commercial potential of inventions, conducted prior art searches and created technology assessment reports for life science and medical device inventions.
• Performed competitive market assessment of various current and upcoming products related to the inventions.
• Developed strategic plans and recommendations for licensing opportunity.

Pittsburgh Life Science Greenhouse, Pittsburgh, PA
Market Research Analyst Intern

• Conducted secondary market research and strategy evaluation for the US $9.8 billion chronic liver disease market and studied its impact on US healthcare.
• Performed competitive analysis of various current and upcoming hepatitis and liver cancer management strategies in the US market and designed a product portfolio analysis to identify current market trends.